Twitter’s popularity has spurred the development of countless high-quality apps that let you use Twitter from the web, desktop or even your mobile phone.

If you’re an avid Twitter user, chances are you’re using one of these Twitter Desktop Applications that basically allow you to receive and post Tweets from your desktop. Meaning, you don’t have to visit your Twitter.com page from time to time to find out  what’s new about your Twitter friends. If you haven’t used a Twitter desktop application before, well this might be the right time to do so. We’ve picked best of the Twitter Desktop Applications available for you to use.

Some of the Twitter clients mentioned here are based on Adobe AIR so you may use them on Linux and Mac as well. Let’s dive in.

1. Blu (Native Windows Twitter Client)

Blu in one word is beautiful. Powered by WPF, Blu showcases your Twitter timeline inside an animated and colorful interface. With Blu, you can reply to your Tweets inline so you don’t lose the current view. Then you can scroll unlimitedly so you can easily see older tweets without having to click anything. But the best part is this – if you see a message in your Twitter stream that is in reply to another tweet, you can click this message to see the original tweet that started the whole conversation. Few Drawback are it doesn’t support multiple Twitter accounts, you cannot follow your lists in Blu, there’s no option to search tweets yet it’s impressive.

2. Destroy Twitter

DestroyTwitter, an Adobe AIR powered Twitter desktop client, is again very popular for its minimalistic but innovative interface. The unique thing about Destroy Twitter is its support for themes – you can either download ready-made themes or use the online theme-builder to create one that matches your taste. DestroyTwitter uses impressive transitions when switching from one screen to another and it’s probably the only desktop client that lets you edit your own Twitter profile. Then there’s support for Twitter trends so that you can know what’s hot on Twitter without having to visit the Twitter site. Destroy Twitter is lightweight and extremely fast. You can also configure the application so that it always stays on top of other applications.

3. DigiTweet

An open source desktop Twitter applications for Windows.  Through Windows Presentation Foundation, DigiTweet provides Twitter functionalities with rich user interface. It’s notable features include search facility for finding other twitter users as well as Twitter contents, and a friends list for viewing  Twitter users you are following and who are following you.

4. Digsby

The beloved IM, email notification, and social networking application also does Twitter, but it’s only available for PCs at the moment. On the social networking side, Digsby pulls in Facebook, MySpace, Twitter, and LinkedIn so you can get a more complete view of what’s happening across your entire social presence.

5. Mixero

AIR powered Mixero is aimed at reducing noise and making it easier for you to keep track of updates that could be more important to you. It offers advanced filtering so you can hide spammers from your Twitter stream (based on usernames or even stop-words), and lets you arrange those you follow into groups that are integrated with Twitter lists. You can preview images from Twitpic, Flickr, YouTube video frames, etc. directly in your timeline. Another good feature in Mixero is “Conversations” – you can click the bubble (speech) icon next to any tweet to find all other previous tweets that may part of that conversation.

6. Mitter

Mitter is a simple crossplatform Twitter client with a clean and fully customizable interface. It supports  docking on systray. It can be easily  integrated with GNOME desktop. Additionally, it offers a console client.

7. PeopleBrowsr

The desktop version is just as complicated and feature-rich as the web app (you’ll need to log in to the website to find the download link in lower right-hand corner) only if you can afford it (But they are giving it for Free till 4th Jan 2010 so Hurry up!). With PeopleBrowsr you get a full-featured Twitter app that is bloated with features like export, sort by Twitter name or number of followers, map or gallery views, stats on stacks (which are like columns), an aggregate view of tweets across stacks, simultaneous posting to other services, quick access to a number of different filters, and so much more. And we haven’t even begun to discuss the integrations with every popular social site on the planet. Even though the light mode is a little easier, this app is better left to extreme power users. Plus all those features seem to really slow it down.

8. Seesmic Desktop for AIR

Seesmic Desktop is the original Adobe AIR powered Seesmic app, and it works with Twitter as well as Facebook (including Facebook Pages). With Seesmic Desktop, you can mark individual tweets as spam, follow new people and unfollow (or even block) other people from your timeline. When sharing images on Twitter, you can either upload images from the desktop or capture a picture right from your webcam. Although Seesmic Desktop will run on any operating system, it uses a Mac OS style UI which doesn’t look that good on a Windows desktop. The best part about Seesmic Desktop is its support for Facebook Pages – you can post new messages or even moderate comments on pages that you own.

9. Seesmic for Windows

Launched during Microsoft PDC ‘09, Seesmic for Windows is a beautiful desktop client for Twitter with a slightly translucent and tabbed interface. Seesmic for Windows can handle multiple Twitter accounts – you can get a combined timeline or look at your @replies, direct messages and sent messages for individual accounts separately. You can post the same update /link /photo to one or more Twitter account simultaneously. This is a native Windows application and doesn’t require Adobe AIR.

10. SharedMinds Desktop

The interface of SharedMinds Desktop for Windows is inspired by Outlook 2007 – you can even change themes from Sliver to Blue as in Microsoft Office. The similarity doesn’t end here – you navigate tweets just like you move across records in an Access database. What’s unique about SharedMinds Desktop is the integrated browser – if there’s a link inside a tweet, you can read the corresponding web page directly inside the Twitter client without having to launch a separate tab in your browser. However, you cannot share pictures and other files with this app.

11. Snitter

This is an Adobe AIR powered Twitter client compatible for Windows. Snitter offers auto updates tweet list, recent list of tweets, 20 most recent items in your timeline, 20 most recent replies,  20 most recent direct messages and more. Further, it has options for viewing and filtering the followers.

12. Sobees for Windows

Sobees offers a fresh interface and allows you to choose your own layout for different social services. Sobees includes an anti-spam feature that will let you block certain words from appearing in your Twitter stream. You can run Sobees on any Windows computer as long as it has .NET installed.

13. Spaz

Spaz is an free open source Twitter client with attractive design and high customizability. Some of its key features include directory listing of users, built in global search, short URL creation tool, markdown syntax support and user-defined CSS overrides. Spaz also offers multiple themes and supports the user defined themes. Additionally, Spaz comes with debugging and development tools.

14. TweetDeck

One of the most popular Twitter apps, TweetDeck is great for managing all your favorite social services including Twitter, Facebook, LinkedIn and MySpace from one place. Its multicolumn interface not only allows you to keep up with all your social accounts but also with Twitter lists and any custom searches that you may have saved inside Twitter. With TweetDeck, you can see a very detailed profile of any Twitter user, you can follow (or unfollow) users and even put them in any of your Twitter lists. TweetDeck supports inline translation so you can easily read foreign language tweets that may appear in your Timeline or search results. If you work across multiple computers, you can setup an account at TweetDeck and that will save you from the hassle of having to configure Tweetdeck on every single computer. And if you are no big fan of Twitter’s retweet function, you can opt for the classic version of “retweet” (RT).

15. Tweetr

A lesser known simple app, Tweetr is beautiful Adobe AIR based app that doesn’t support multiple accounts, and isn’t right for power users, but might be just perfect for lightweight Twitterers. You’re not going to get columns, groups, search, or filters, but you can share files and take photos with your web cam.

16. TweetyBot

This is most simplistic Twitter desktop application for Windows. TweetyBot includes some exquisite features. It features a number of tabs with options for tweet, replies, directs and more. In addition, this Twitter client allows you to manage the Tweets. One of its best features is the Alert list tab. It provides pop-up alerts when your favorite twitterers update their status.

17. Twhirl from Seesmic

Twhirl is a quick and easy-to-use Twitter client with a minimal yet beautiful UI. You can even choose your own color schemes and font styles for the UI. Unlike heavy-weights like Seesmic or TweetDeck, Twhirl doesn’t offer loads of features but if all you need is a way to quickly post status updates on your Twitter timeline, this could be a good choice. Twirl also offers integration with other less-common networks such as identi.ca and FriendFeed, and lets you cross-post updates to other social networks via Ping.fm. Twhirl is from Seesmic, the same company the develops previously mentioned Seesmic Desktop for AIR and Seemsmic for Windows.

18. Twitteroo

Twitteroo is a feature-rich Twitter client for Windows. This exclusive twitter client provides you with Twitter notifications, URL shortening and viewing friends timeline or public timeline. Browse to Twitter user page or personal websites.

19. Twunami

20. Witty

Witty is a free open source Twitter client for Windows. It is powered by Windows Presentation Foundation(WPF). This Twitter client allows you to view status updates, replies, specific user’s timeline, twitter status, response to direct messages and more. It provides the links to open the users default browser. The new messages are highlighted with yellow fade technique. The beta version is also available.

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